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OUR INGREDIENT
Structure of 'Methionyl r-Clostridium
Botulinum Polypeptide-1 Hexapeptide-40'
'Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40' is developed as recombination of peptide called “MTD” (Macro-molecule Transmission Domain) that has function of skin and target cell permeation and, active protein of botulinum toxin called 'Light Chain'. 'MTD' applied to our ingredient is originated and developed from botulinum toxin 'Heavy Chain', ,which performing a cell-penatration function of botulinum toxin.
Toxin Complex
(Medical Botox Injection)
Botulinum Light Chain A
Botulinum Heavy Chain
Hemaggultinin
Non-toxin
Non-toxin Non-Hemagglutinin
Composition
Heavy chain : Nerve cell penetration
Light chain : Botulinum Efficacy Part
Hemagglutinin
Non-toxin Non-Hemagglutinin
Commercialization
1980
Example
BOTOX (Allergan, US)
MEDITOXIN (Meditox, Korea)
Not permitted to use in Cosmetic Product
Molcular weight
900KDa
Pure Toxin
(Medical Botox Injection)
Botulinum Light Chain A
Botulinum Heavy Chain
Heavy chain : Nerve cell penetration
Light chain : Botulinum Efficacy Part
1995
XEOMIN (Merz, Germany)
Not permitted to use in Cosmetic Product
150KDa
Our Ingredient
(BPMed_BoLCA_Protein)
Botulinum Light Chain A
MTD Protein
Light Chain + MTD
Botulinum Efficacy Part
Marco-molecule Transmission Domain
(Skin & Nerve cell penetration)
= Recombination of the Protein
2014
BoLCA+ (BPMed cosmetic, Korea)
The First Botulinum Ingredient on ICID
BPMed Cosmetic has Exclusivity
50KDa
COMPARISON IF BOTULINUM INGREDIENTS
Platform technology to improve transdermal delivery of
'Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40'
1st Action
2nd Action
Improved penetration of functional materials into stratum corneum and other skin layers by MTD.
Maximized efficacy through the delivery of 'Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40' into specific targets.
Epidermis
Dermis
Subcutaneous Tissue
Muscle Layer
Cell
SKIN AND CELL PENETRATION TECHNOLOGY OF MTD
Cell
Macro-molecule Transmission Domain (MTD)
Botulinum Light Chain
Cell-To-Cell Delivery
Modality of Intracellular delivery of MTD in 'Methionyl
r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40'
Permeate in to cell by MTD technology shows very high Permeability and significantly less cell damage then nano liposome or common peptide ingredients(PTD).
MECHANISM ON NERVE CELL
Normal Neurotransmission Process
01
SNARE Complex Exocitosis
Acetylcholine Diffusion Binds
to the Receptors on the Muscle
Penetrated in to dermis layer
02
Methionyl r-Clostridium Botulinum
Polypeptide-1 Hexapeptide-40
Nerve Cell
03
Approaching to the Cell
04
Direct Cell Membrane Translocation
SNAP 25
05
Moves to the SNAP25
06
Cleaves SNAP25 by Light Chain Part